A ketoglutarat dehydrogenase
KAT2A coupled with the α-KGDH complex acts as a - Nature Step 4. α-ketoglutarate is converted to succinyl CoA in a reaction catalyzed by α-ketoglutarate dehydrogenase. An NAD+ molecule is reduced to NADH + H+ in this reaction, which also takes a SH-CoA molecule as reactant. A carbon dioxide molecule is released as a product.
The α-Ketoglutarate Dehydrogenase Complex as a Hub of Oxoglutarate dehydrogenase is a key control point in the citric acid cycle. It is inhibited by its products, succinyl CoA and NADH. A high energy charge in the cell will also be inhibitive. ADP and calcium ions are allosteric activators of the enzyme.
A-ketoglutarate dehydrogenase The α-Ketoglutarate Dehydrogenase Complex as a Hub of Plasticity in Neurodegeneration and Regeneration Authors Grace E Hansen 1, Gary E Gibson 2 Affiliations 1 Department of Biology, University of Massachusetts, Lowell, MA , USA.
Alpha-ketoglutarate dehydrogenase: a target and generator of At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron transport chain activity and tricarboxylic acid cycle (TCA) flux, and is a pivotal enzyme in the metabolic reprogramming following a cancer cell’s change in bioenergetic .
The alpha-ketoglutarate dehydrogenase complex - PubMed It catalyses the conversion of α-ketoglutarate to succinyl-CoA and produces NADH directly providing electrons for the respiratory chain. α-KGDH is sensitive to reactive oxygen species (ROS) and inhibition of this enzyme could be critical in the metabolic deficiency induced by oxidative stress.
Structural basis for the activity and regulation of human α The alpha-ketoglutarate dehydrogenase complex (KGDHC) is an important mitochondrial constituent, and deficiency of KGDHC is associated with a number of neurological disorders. KGDHC is composed of three proteins, each encoded on a different and well-characterized gene. The sequences of the human proteins are known.
The α-ketoglutarate dehydrogenase complex in cancer metabolic α-Ketoglutarate is a key intermediate in the Krebs cycle, coming after isocitrate and before succinyl CoA. Anaplerotic reactions can replenish the cycle at this juncture by synthesizing α-ketoglutarate from transamination of glutamate, or through action of glutamate dehydrogenase on glutamate.
OGDH Gene - GeneCards: ODO1 Protein: ODO1 Antibody
Die α-Ketoglutarat-Dehydrogenaseist ein Multienzymkomplex, der im Citratzyklusdie oxidative Decarboxylierungvon α-Ketoglutaratzu Succinyl-CoAkatalysiert. Hintergrund Der Citratzyklusist ein zyklischerStoffwechselwegim Mitochondrium. Seine wichtigste Aufgabe besteht darin, Acetylrestezu oxidieren, um Elektronenfür die Atmungskettezu gewinnen.